C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/496 (2006.01) A61L 27/54 (2006.01) A61L 31/16 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2687766
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
La présente invention concerne des composés qui agissent en tant que puissants antagonistes du récepteur CCR1 et qui présentent une activité anti-inflammatoire in vivo. Les composés sont généralement des dérivés d'aryle pipérazine et ils sont utilisables dans des compositions pharmaceutiques, dans des procédés de traitement de maladies soignées par le CCR1 et en tant que témoins dans des dosages d'identification des antagonistes de compétition du CCR1.
Chen Wei
Gleason Mark M.
Greenman Kevin Lloyd
Leleti Manmohan R.
Li Lianfa
Chemocentryx Inc.
Fetherstonhaugh & Co.
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