Azaindazole compounds and methods of use

Details Azaindazole compounds and methods of use Azaindazole compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2612552

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Composés qui agissent en tant qu'antagonistes puissants du récepteur CCR1 et possèdent une activité anti-inflammatoire in vivo. Lesdits composés sont généralement des dérivés d'aryle pipérazine et sont utiles dans des compositions pharmaceutiques, dans des méthodes de traitement de maladies médiées par CCR1, et en tant que témoins dans des analyses pour l'identification d'antagonistes compétitifs de CCR1.

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