Azaindazole compounds as ccr1 receptor antagonists

Details Azaindazole compounds as ccr1 receptor antagonists Azaindazole compounds as ccr1 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2737472

Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

La présente invention concerne des composés de formule (I), utiles pour le traitement dune variété de maladies et de troubles qui sont médiés ou prolongés par lactivité de CCR1 qui comprennent des maladies auto-immunes, telles que la polyarthrite rhumatoïde et la sclérose en plaques. La présente invention concerne également des procédés de fabrication et dutilisation de ces composés.

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