C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/5025 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2627349
Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds include azaindoles of the formula below [insert figure 6c] in which at least one of CR4, CR5, CR6 and CR7 is replaced by N, and the groups R1-R7 are defined as in claim 1.
L'invention concerne de l'indole et des composés apparentés à l'indole, des compositions et des méthodes. Les composés de l'invention sont utiles en tant qu'inhibiteurs de phospholipases. Les composés et compositions de l'invention sont utiles pour le traitement d'états liés aux phospholipases, tels que les états liés à l'insuline, liés au poids et/ou liés au cholestérol chez un sujet animal.
Buysse Jerry M.
Chang Han-Ting
Charmot Dominique
Chen Shiah-Yun
Cope Michael James
Ilypsa Inc.
Ridout & Maybee Llp
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