Azaindole derivatives as cftr modulators

Details Azaindole derivatives as cftr modulators Azaindole derivatives as cftr modulators

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2668305

The present invention relates to. modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof of formula (I), including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

La présente invention concerne des modulateurs de transporteurs de cassette de liaison à l'ATP ('ABC') ou leurs fragments, y compris le Régulateur de conductance transmembranaire de la fibrose kystique ('CFTR'), des compositions les comprenant et des procédés les utilisant. La présente invention concerne également des procédés permettant de traiter des maladies impliquant des transporteurs ABC en utilisant de tels modulateurs.

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