C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/04 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01)
Patent
CA 2411865
Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I), as per the specification, and wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, - (CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R2 is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed; these compounds are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity.
Nouveaux 1H-pyrrolo[2,3-b]pyridines correspondant à la formule (I), selon la spécification, dans laquelle R est un atome d'hydrogène ou d'halogène ou un groupe sélectionné entre -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, ou -(CH2)nNHSO2R4, dans lesquelles n est 0 ou 1, R4 est R5 sont décrits dans la spécification; R1 est hydrogène ou un groupe alkyle éventuellement substitué; R2 est groupe éventuellement substitué sélectionné parmi alkyle ou aryle; R3 est hydrogène ou un groupe sélectionné entre -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulfonylaminocarbonyle ou alkylsulfonylaminocarbonyl perfluoré; ou son sel pharmaceutiquement acceptable; ces composés sont utiles pour traiter les troubles prolifératifs associés à une activité de kinase dépendant du cycle cellulaire modifié.
Brasca Maria Gabriella
Longo Antonio
Orsini Paolo
Pevarello Paolo
Pittala Valeria
Pharmacia & Italia S.p.a.
Smart & Biggar
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