C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61K 45/06 (2006.01) A61P 13/08 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2492665
The present invention provides compounds of formula (I), (I) and pharmaceutically acceptable salts thereof.The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR- 1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
La présente invention concerne des composés de formule I, et leurs sels pharmaceutiquement acceptables. Les composés de formule I inhibent l'activité de la tyrosine kinase de récepteurs de facteur de croissance, notamment VEGFR-2 et FGFR-1, ce qui leur confère une propriété anticancéreuse. Les composés de formule I se prêtent également au traitement d'autres maladies associées aux voies de transduction de signal fonctionnant à travers les récepteurs de facteur de croissance.
Bhide Rajeev
L'heureux Alexandre
Ruel Rejean
Thibeault Carl
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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