Azaindoles as inhibitors of c-jun n-terminal kinases

Details Azaindoles as inhibitors of c-jun n-terminal kinases Azaindoles as inhibitors of c-jun n-terminal kinases

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2479205

The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.

L'invention concerne de nouveaux composés de 7-azaindole substitués en position 5 de formule (I), leur utilisation pour inhiber des kinases à terminaison c-Jun N, en médecine et en particulier pour prévenir et/ou traiter des troubles neurodégénératifs associés à une apoptose et/ou une inflammation. La présente invention porte également sur des procédés pour préparer ces composés, sur des préparations les contenant et sur des procédés pour réaliser ces préparations.

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