Azaindoles modulating c-kit activity and uses therefor

Details Azaindoles modulating c-kit activity and uses therefor Azaindoles modulating c-kit activity and uses therefor

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/444 (2006.01) A61P 11/06 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2570817

Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c kit ligand identification and design.

L'invention concerne des composés qui présentent une structure de noyau 7-azaindole et une activité se rapportant à la tyrosine kinase c-kit de la protéine réceptrice. Elle concerne également des compositions utiles pour le traitement de maladies ou de pathologies induites par c-kit, et des méthodes d'utilisation desdites compositions. Elle concerne en outre des méthodes d'identification et de mise au point de ligand c-kit.

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