Azaindolizines and methods of use

Details Azaindolizines and methods of use Azaindolizines and methods of use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2708176

The invention relates to azaindolizines of formula I-a or I-b with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolizines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro,in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

L'invention concerne des azaindolizines de formule I-a ou I-b présentant une activité anticancéreuse et/ou anti-inflammatoire et plus spécifiquement des azaindolizines qui inhibent l'activité MEK kinase. L'invention propose des compositions et des procédés utiles pour inhiber la prolifération cellulaire anormale ou traiter un trouble hyperprolifératif, ou pour traiter une pathologie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour le diagnostic ou le traitement in vitro, in situ et in vivo de cellules de mammifère, ou des états pathologiques associés.

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