Azalide antibiotic compositions

Details Azalide antibiotic compositions Azalide antibiotic compositions

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01) A61P 33/02 (2006.01) C07H 17/00 (2006.01)

Patent

CA 2398485

Antibiotic compositions comprising an equilibrium mixture of azalide isomers, water, and one or more acids, and methods for preparing such compositions, are disclosed. The antibiotic compositions can be advantageously stabilized by adding one or more water-miscible co-solvents. In a preferred embodiment, the one or more co-solvents is propylene glycol.

La présente invention concerne d'une part des compositions antibiotiques contenant un mélange à l'équilibre d'isomères azalide, d'eau, et d'un ou plusieurs acides, et d'autre part de procédés de préparation de ces compositions. On peut avantageusement stabiliser des compositions antibiotiques en ajoutant un ou plusieurs co-solvants miscibles à l'eau. Dans un mode préféré de réalisation, un ou plusieurs co-solvant(s) représente(nt) propylène glycol.

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