Azanoradamantanes

Details Azanoradamantanes Azanoradamantanes

C - Chemistry, Metallurgy

07

D

C07D 471/18 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2151282

This invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein Z is selected from the group of (a) and (b); R1 is alkoxy of one to six carbon atoms; R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, halogen, CF3, hydroxy, alkoxy of one to six carbon atoms, acyl of two to seven carbon atoms, amino, amino substituted by one or two alkyl groups of one to six carbon atoms, C2-C7 acylamino, aminocarbonyl, aminosulfone optionally substituted by one or two alkyl groups of one to six carbon atoms, C1-C6 alkylsulfone and nitro; n is 0, 1 or 2; m is 0 or 1; X is O or NR7; and R7 is hydrogen or alkyl of 1 to 6 carbon atoms, which act as 5-HT4 agonists or antagonists and/or 5-HT3 antagonists in mammals.

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