Azapeptide derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/42 (2006.01) A61K 31/4418 (2006.01) A61K 31/675 (2006.01) A61P 31/18 (2006.01) C07F 9/58 (2006.01)

Patent

CA 2692028

This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.

La présente invention concerne de nouveaux composés d'azapeptides, et leurs sels pharmaceutiquement acceptables. De manière plus spécifique, l'invention concerne de nouveaux composés d'azapeptide qui sont des dérivés du sulfate d'atazanavir, un inhibiteur de la protéase du VIH,. La présente invention concerne également des compositions apyrogènes contenant un ou plusieurs composés de l'invention et un excipient, ainsi que l'utilisation des composés et compositions décrits dans les procédés de traitement de pathologies et de troubles qui sont traitées par l'administration d'inhibiteurs de la protéase du VIH. L'invention concerne également l'utilisation d'un ou de plusieurs des composés décrits en tant que réactifs dans des études analytiques impliquant l'atazanavir.

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