C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/20 (2006.01) A61K 31/438 (2006.01) A61P 9/12 (2006.01) A61P 25/24 (2006.01)
Patent
CA 2674154
The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I) wherein R1 to R6, U, V, W, X, Y and Z are as defined in the specification.
Nouveaux dérivés d'indol-3-yl-carbonyl-azaspiropipéridine en tant qu'antagonistes du récepteur V1a, leur production, des compositions pharmaceutiques les contenant et leur utilisation en tant que médicaments. Les composés actifs selon la présente invention sont utiles pour prévenir et / ou traiter l'anxiété et les troubles dépressifs ainsi que d'autres maladies. En particulier, la présente invention concerne des composés de formule générale (I) dans laquelle R1 à R6, U, V, W, X, Y et Z sont tels que définis dans le descriptif.
Bissantz Caterina
Grundschober Christophe
Masciadri Raffaello
Ratni Hasane
Rogers-Evans Mark
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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