Azaspyro¬4.5|decane-7,9-dione derivatives and process for...

Details Azaspyro¬4.5|decane-7,9-dione derivatives and process for... Azaspyro¬4.5|decane-7,9-dione derivatives and process for...

C - Chemistry, Metallurgy

07

D

260/263, 260/278

C07D 401/06 (2006.01) C07D 221/20 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2036269

ABSTRACT THE INVENTION RELATES NEW AZASPYRO[4.5]DECANE-7,9-DIONE DERIVATIVES of general formula (I): (I) Image where n is 2 or 4; B can be a nitrogen atom or a -CH-group; Z can be the radical (pyrimidine 2 yl)amino, the radical 3-tri- fluoromethylphenyl and the radical benzimidazole-2-yl, substi- tuted in position 1 with short chain alkyl radicals or with a phenylmethyl radical, with or without substituents in the ring. The invention also relates to a process for preparing the afore- mentioned compounds. The process comprises reacting a primary amine of formula (II) Image (II) with 3,3-tetramethyleneglutaric acid and recovering the desired product.

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