C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 3/06 (2006.01) A61K 31/7008 (2006.01) A61K 31/702 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2564224
The invention concerns heparanase inhibiting compounds of general formula (I) wherein R represents a hydrogen atom, an hydroxyl radical, a -OSO3- radical, a -O-(C1-C5)alkyl radical or an -O- aralkyl radical; Z represents a COO- radical or a hydroxyl radical; X represents -OH or a saccharide unit of formula A, Y represents H, C1-C5 alkyl or a saccharide unit of formula D; in free form or in the form of pharmaceutically acceptable salts formed with a base or an acid as well as in the form of solvates or hydrates. The derivatives of the invention are useful as medicines.
La présente invention concerne les composés inhibiteurs d'héparanases, répondant à la formule générale (I) : dans laquelle : R représente un atome d'hydrogène, un radical hydroxyle, un radical -OSO3-, un radical -O-(C1- C5)alkyle ou un radical -O-aralkyle ; Z représente un radical COO- ou un radical hydroxyle X représente -OH ou une unité saccharidique de formule A ; Y représente H, (C1-C5)alkyle ou une unité saccharidique de formule D ; sous forme libre ou sous forme de sels formés avec une base ou un acide pharmaceutiquement acceptables ainsi que sous forme de solvats ou d'hydrates. Médicaments.
Driguez Pierre Alexandre
Petitou Maurice
Kirby Eades Gale Baker
Sanofi-Aventis
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