C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/18 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) C07D 487/08 (2006.01) C07D 487/18 (2006.01)
Patent
CA 2041224
The invention relates to azatetracycle compounds of the formula Image wherein A is NH or a covalent bond, wherein p is 1 or 0, Ar is an aromatic moiety, B is NH or O, and D is the tetracyclic structure Image The compounds are useful in the treatment of gastroin- testinal motility disorders such as gastroesophageal reflex, non-ulcer dyspepsia, delayed gastric emptying, ileus, irritable bowel syndrome, and the like. The com- pounds are also useful as 5-HT3 antagonists. The com- pounds are therefore useful as antiemetics, analgesics, anxiolytics, and exhibit utility in the treatment of substance abuse, schizophrenia, depression, and migraine headaches, presenile and senile dementia (i.e., Alzhei- mer's disease and senile dementia of the Alzheimer type), and enhancers of intra-nasal absorption of bio- active compounds.
Becker Daniel P.
Flynn Daniel L.
Nosal Roger
Spangler Dale P.
Zabrowski Daniel L.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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