Azatetracyclic carbonitriles

Details Azatetracyclic carbonitriles Azatetracyclic carbonitriles

C - Chemistry, Metallurgy

07

D

260/241.15

C07D 491/044 (2006.01) C07C 59/68 (2006.01) C07D 313/14 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1152987

4-12628/10498/+ Azatetracyclic carbonitriles Abstract Azatetracyclic carbonitriles of the formula Image (I) in which R represents hydrogen, lower alkyl, cycloalkyl-lower alkyl having up to 10 carbon atoms, lower alkenyl, lower alkynyl or free, etherified or esterified hydroxy-lower alkyl, and acid addition salts thereof, processes for their manufacture, pharmaceutical compositions that contain such compounds and their use. They are distinguished especially by their central nervous system-depressant, agitation-inhibitory (amphetamine-antagonistic) action. They can therefore be used as tranquillising, anti- psychotic, agitation-inhibitory compounds for the treatment of agitated states having various causes.

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