Azavesamicols

Details Azavesamicols Azavesamicols

C - Chemistry, Metallurgy

07

D

C07D 211/18 (2006.01) A61K 31/445 (2006.01) A61K 31/4545 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 49/08 (2006.01) A61K 51/04 (2006.01) C07D 211/56 (2006.01) C07D 401/04 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2134338

2134338 9324457 PCTABS00028 The compounds are vesamicol (hydroxylated phencyclidine(PCP) isomer trans-2-(4-phenyl-piperidino)cyclohexanol) derivatives with anticholinergic properties termed herein "azavesamicols" in which the cyclohexyl group of vesamicol is replaced with a heterocycle of similar size, the piperidyl ring. The coumpounds bind to the vesamicol receptor, a cytoplasmically-oriented site on the cholinergic synaptic vesicle, which is associated with the vesicular transporter of acetylcholine.

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