Azelastine hydrochloride-containing percutaneous preparation...

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61K 9/06 (2006.01) A61K 47/10 (2006.01) A61K 47/44 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2264693

A percutaneous preparation which comprises: 0.001 to 5 weight % of azelastine hydrochloride; 10 to 97 weight % of at least one hydrocarbon and/or beeswax, wherein said hydrocarbon is selected from the group consisting of white petrolatum, yellow petrolatum, and gelatinized hydrocarbon; 0.5 to 35 weight % of at least one higher alcohol and/or polyhydric alcohol, wherein said higher alcohol is selected from the group consisting of stearyl alcohol, cetanol, and cetostearyl alcohol, and wherein said polyhydric alcohol is selected from the group consisting of propylene glycol and polyethylene glycol; and 0.5 to 10 weight % of at least one surfactant selected from the group consisting of polyoxyethylene hydrogenated castor oil, glycerol monostearate, polyoxyethylene lauryl ether and cholesterol; and wherein said composition does not contain a fatty acid having 8 or more carbon atoms. Has a reduced skin irritation and good percutaneous absorbability of azelastine hydrochloride (active ingredient).

Cette invention se rapporte à une préparation percutanée contentant de l'hydrochlorure d'azélastine, cette préparation renfermant comme constituant de base: un composé hydrocarbure et/ou de la cire d'abeilles et un tensioactif. Cette préparation est très utile dès lors qu'elle présente une action réduite d'irritation de la peau et une excellente propriété d'absorbabilité percutanée de l'hydrochlorure d'azélastine comme principe actif.

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