Azepane derivatives and their use as atk1 inhibitors

Details Azepane derivatives and their use as atk1 inhibitors Azepane derivatives and their use as atk1 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 223/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2478276

This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula ( I ) wherein the remaining symbols have the significance given in the specification, as well as processes for their manufacture. The compounds according to this invention possess anti-cell proliferation activity and show an increased plasma- stability.

Cette invention, qui a trait à de nouveaux dérivés d'azépane ou à leurs sels, admissibles du point de vue pharmaceutique, correspondant à la formule générale (I), formule dans laquelle les symboles sont tels que définis dans le descriptif, concerne également des procédés de production de des dérivés. Les composés selon l'invention agissent contre la prolifération cellulaire et témoignent d'une stabilité plasmatique accrue.

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