Azepines-derivatives, the preparation thereof and their use...

Details Azepines-derivatives, the preparation thereof and their use... Azepines-derivatives, the preparation thereof and their use...

C - Chemistry, Metallurgy

07

D

260/241.15

C07D 487/04 (2006.01) C07D 223/06 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1171084

ABSTRACT OF THE DISCLOSURE Compounds of general formula I (I) Image wherein R1 represents a hydrogen atom, an alkyl, alkenyl, alkoxycarbonyl or alkoxycarbonyl group, or an optionally substituted aralkyl or benzoyl group; one of the groups R2 or R3 represents a hydrogen atom or an amino group and the other group R2 or R3 represents a carboxy or alkoxycarbonyl group or (if R3 represents a hydrogen atom) R2 may also represent a hydrogen atom, an amino, alkoxycarbonylamino, azidocarbonyl, hydrazinocarbonyl, phenylaminocarbonyl or phenylethylamino- carbonyl group wherein the phenyl nucleus may be substituted by a carboxy or alkoxycarbonyl group; and X represents an oxygen or sulphur atom or an optionally substituted imino group; and salts thereof formed with acids for bases. Processes for the preparation of the new compounds are also described. The new compounds show valuable pharmacological properties, especially an antithrombotic effect and an effect on intermediary metabolism.

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