C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2555279
Compounds for use in pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the farnesoid X receptor, and/or orphan nuclear receptors, are provided.: formula (I) or a pharmaceutically acceptable derivative thereof; wherein: R1 is -C(J)OR14, - C(J)SR14 and -C(J)N(R15)R16, J is O, S or NR17, R2 is hydrogen, halo or optionally substituted alkyl; R3 is -C(O)R9, R4, R5, R6 and R7 and R8 are as described in the claims.
Cette invention concerne des composés, des compositions et des méthodes permettant de moduler l'activité de récepteurs. L'invention concerne en particulier des composés et des compositions qui assurent la modulation de certains récepteurs et qui interviennent dans le traitement, la prévention ou l'atténuation d'un ou de plusieurs symptômes de maladie ou de trouble en rapport direct ou indirect avec l'activité de ces récepteurs.
Busch Brett
Flatt Brenton T.
Gu Xiao-Hui
Martin Richard
Mohan Raju
Bennett Jones Llp
Exelixis Inc.
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