Azetidine derivatives and their use as prostaglandin e2...

Details Azetidine derivatives and their use as prostaglandin e2... Azetidine derivatives and their use as prostaglandin e2...

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61P 29/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2686517

The present invention relates to a class of EP2 antagonist azetidines of general formula (I) wherein the variables and substituents are as defined herein, and especially to EP2 antagonist compounds, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids (leiomyomata) and to intermediates useful in their synthesis and to compositions containing them.

La présente invention concerne une classe d'azétidines antagonistes des EP-2 de formule générale (I) où les variables et groupes substituants sont comme définis dans la description, et concerne en particulier les composés antagonistes des EP-2, leur utilisation en médecine, en particulier dans le traitement de l'endométriose et/ou des fibromes utérins (léiomyomatose) et les intermédiaires utiles dans leur synthèse et les compositions les contenant.

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