C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/497 (2006.01) A61P 3/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2739466
Azetidine derivatives of structural formula I are inhibitors of stearoyl- coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.
L'invention porte sur des dérivés d'azétidine, représentés par la formule de structure I, qui sont des inhibiteurs de la stéaroyl-coenzyme A delta-9 désaturase (SCD). Les composés de la présente invention sont utiles pour la prévention et le traitement d'affections liées à une synthèse et à un métabolisme anormaux des lipides, comprenant les maladies cardiovasculaires; l'athérosclérose; l'obésité; le diabète; les maladies neurologiques; un syndrome métabolique; l'insulinorésistance; le cancer; la stéatose hépatique, et la stéatose hépatique non alcoolique.
Powell David
Tranmer Geoffrey K.
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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