C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/40 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2733397
The invention relates to compounds of the formula (I) where: R is a (C1-C6)alkyl group, a halo(C1-C6)alkyl group; R1 is a hydrogen atom; R2 is a heteroaromatic group or a heteroaromatic(C1-C4)alkyl group, said groups being optionally substituted; R3 and R4 represent independently from each other an optionally substituted phenyl group; Y is a hydrogen atom, a halogen, a cyano, a (C1-C6)alkyl group, a halo(C1-C6)alkyl group, a (C1-C6)alkoxy group, a halo(C1-C6)alkoxy group or a (C1-C6)alkylS(0)p group; and p is 0 to 2. Said compounds can be in the form of a base or a salt for addition to an acid. The invention also relates to a method for preparing same and to the therapeutic application thereof.
Composés répondant à la formule (I) dans laquelle : R représente un groupe (C1- C6)alkyle, un groupe halo(C1--C6)alkyle; R1 représente un atome d'hydrogène; R2 représente un groupe hétéroaromatique ou un groupe hétéroaromatique (C1--C4)alkyle, ces groupes étant éventaellement substitués; R3 et R4 représentent indépendamment l'un de l'autre un groupe phényle, éventaellement substitué; Y représente un atome d'hydrogène, un halogène, un cyano, un groupe (C1-C6)alkyle, un groupe halo(C1-C6)alkyle, un groupe (C1-C6)alcoxy, un groupe halo(C1-C6)alcoxy ou un groupe (C1- C6)alky1S(O)p; p est compris entre 0 et 2; à l'état de base ou de sel d'addition à un acide. Procédé de préparation et application en thérapeutique.
Bernardelli Patrick
Sabuco Jean-Francois
Terrier Corinne
Robic
Sanofi-Aventis
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