C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61P 3/04 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2524251
Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors such as obesity: Formuila (I) wherein: R1 and R2 are independently selected from aryl; and R3 is hydrogen or alkyl; or a pharmaceutically acceptable salt or prodrug thereof, wherein at least one of R1 and R2 has a non-hydrogen substituent in the ortho- position(s) thereof relative to the point of attachment to the [-CH-0-] group.
L'invention concerne des composés de formule (I), ou un sel ou un promédicament pharmaceutiquement acceptable desdits composés, ainsi que leur utilisation à des fins thérapeutiques, notamment pour le traitement d'un trouble médié par les récepteurs CB¿1? tel que l'obésité. Dans la formule (I), R?1¿ et R?2¿ sont indépendamment choisis parmi aryle, R?3¿ est hydrogène ou alkyle, et l'un au moins de R?1¿ et R?2¿ comprend un substituant non hydrogène en position(s) ortho par rapport au point de fixation du groupe [-CH-O-].
Davidson James Edward Paul
Dawson Claire Elizabeth
Harrison Kerry
Mansell Howard Langham
Pratt Robert Mark
Gowling Lafleur Henderson Llp
Vernalis Research Limited
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