Azetidines as ep2 antagonists

Details Azetidines as ep2 antagonists Azetidines as ep2 antagonists

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/41 (2006.01) A61P 15/00 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2705368

The present invention relates to a class of EP2 antagonistazetidinesof general formula (I), wherein the variables and substituents are as defined herein,and especially to EP2 antagonist compounds, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids (leiomyomata)and to intermediates usefulin their synthesis and to compositions containing them. Image

La présente invention concerne une classe d'azétidines antagonistes d'EP2 de formule générale (I), dans laquelle les variables et les substituants sont tels que définis dans le présent document, et notamment des composés antagonistes d'EP2, leur utilisation en médecine, notamment dans le traitement de l'endométriose et/ou des fibromyomes utérins (léiomyomes) et les intermédiaires utiles dans leur synthèse, ainsi que des compositions les contenant.

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