Azetidinone derivatives, a process for their preparation and...

Details Azetidinone derivatives, a process for their preparation and... Azetidinone derivatives, a process for their preparation and...

C - Chemistry, Metallurgy

07

F

260/260, 260/299

C07F 9/568 (2006.01) C07D 205/08 (2006.01) C07D 403/12 (2006.01) C07D 477/04 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1232903

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) (wherein R1 represents hydrogen or a hydroxy- protecting group, R2 and R3 represent hydrogen, alkyl or aryl; R4 represents optionally substituted alkyl, alicyclic heterocyclic, aryl. aromatic heterocyclic, optionally substituted alkenyl or optionally substituted alkynyl: R5 represents hydrogen or a carboxy-protection group: and R6 represents alkoxy, aryloxy,dialkylamino or diarylamino or two or R6 together represent o-phenylenedioxy or three togather represent CH3C(-CH2O-)3) may be prepared by reaxting the corresponding carbonyl compound with a compound of formula P(R6)3. Compounds (I) may be cyclised to prepare carbopenem derivatives, many of which have valuable antibiotic activity.

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