Azetidinone derivatives as .beta.-lactamase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 205/085 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2301523

Novel 2-oxo-1-azetidine sulfonic acid derivatives which are potent inhibitors of bacterial .beta.-lactamases, particularly against class C .beta.- lactamases. Pharmaceutical compositions contain these compounds, and optionally also a .beta.-lactam antibiotic. The compounds and compositions can be used to inhibit .beta.-lactamase inactivation, and for the treatment of bacterial infections.

L'invention concerne des dérivés de l'acide 2-oxo-1-azétidine-sulfonique qui sont de puissants inhibiteurs des .beta.-lactamases bactériennes, notamment des .beta.-lactamases de la classe C; ainsi que des compositions pharmaceutiques contenant lesdits composés et éventuellement une bêtalactamine. Ces composés et ces compositions peuvent être utilisés pour inhiber l'inactivation des .beta.-lactamases et traiter les infections bactériennes.

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