Azide free process for preparing neuraminidase inhibitors r6

Details Azide free process for preparing neuraminidase inhibitors r6 Azide free process for preparing neuraminidase inhibitors r6

C - Chemistry, Metallurgy

07

C

C07C 209/14 (2006.01) C07C 209/16 (2006.01) C07C 229/48 (2006.01) C07C 233/52 (2006.01) C07D 203/26 (2006.01)

Patent

CA 2517458

The invention provides a mufti-step process for preparing 1,2-diamino compounds of formula wherein R1, R1, R2~ RTand R3 have the meaning given in the specification and pharmaceutically acceptable addition salts thereof, from 1,2-epoxides of formula wherein Rl, R1, R2 and R2' have the meaning given in the specification.

L'invention concerne un procédé à plusieurs étapes permettant de préparer des composés 1,2-diamino de la formule où R?1¿, R?1'¿, R?2¿ R?2'¿ et R?3¿ ont la signification donnée dans la spécification, et leurs sels d'addition pharmaceutiquement compatibles, des 1,2-époxides de la formule où R?l¿, R?1¿, R?2¿ et R?2'¿ ont la signification donnée dans la spécification.

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