Aziridine phenethanolamine derivatives

Details Aziridine phenethanolamine derivatives Aziridine phenethanolamine derivatives

C - Chemistry, Metallurgy

07

D

260/328.2, 260/3

C07D 203/08 (2006.01) C07D 295/135 (2006.01) C07D 295/26 (2006.01) C07D 333/22 (2006.01) C07D 333/24 (2006.01) C07D 333/38 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 1219865

Abstract Aziridine and phenethanolamine derivatives of formulae I and II-l Image I-l II-l wherein R1 and R2 signify hydrogen or lower-alkyl; Z1 signifies phenyl or a phenyl group substituted in a defined manner, Z2 and Z21 signify a phenyl or thienyl group substituted in a defined manner and n signifies 1-4 have catabolic activity and can be used for the treatment of obesity and/or of sugar illnesses. The compounds of formula I are obtained by dehydrating .beta.-aminoalcohols (e.g. those of formula II-1) which, in turn, can be prepared by adding amines to epoxides or by reducing corresponding iminoketones, iminoalcohols .alpha.-keto-.beta.-hydroxyamines or .beta.-ketoamines.

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