Azithromycin dihydrate

Details Azithromycin dihydrate Azithromycin dihydrate

C - Chemistry, Metallurgy

07

H

167/185, 260/230

C07H 17/00 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1314876

72222-84 ABSTRACT OF THE DISCLOSURE Disclosed are crystalline azithromycin (9-deoxo-9a-aza- 9a-methyl-9a-homoerythromycin) dihydrate and a process for producing the same. The crystalline dihydrate is non-hygroscopic and is easier to prepare and maintain the product in a form having a constant reproducible water content then hygroscopic monohydrate. The dihydrate is produced by crystallization from tetrahydrofuran and aliphatic hydrocarbon in the presence of a sufficient amount of water.

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