C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 11/02 (2006.01) A61F 2/14 (2006.01) A61L 27/00 (2006.01) A61L 27/28 (2006.01) A61L 27/34 (2006.01) A61L 27/50 (2006.01) C07C 45/71 (2006.01) C07C 49/84 (2006.01) C08F 8/30 (2006.01) C12M 3/04 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2136728
Azlactone-functional substrates (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalent- ly couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reac- tion, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.
Capecchi John T.
Heilmann Steven M.
Krepski Larry R.
Kwon Oh-Seung
Olson David B.
Minnesota Mining And Manufacturing Company
Smart & Biggar
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