C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61P 25/04 (2006.01) A61P 43/00 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) A61K 31/4545 (2006.01)
Patent
CA 2730793
[Problems] A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. [Means for Solution] The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridin-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
L'invention porte sur un composé utile comme ingrédient actif pour une composition pharmaceutique pour le traitement de la douleur neurogénique. Des études approfondies ont été faites sur des composés ayant une activité inhibitrice sur la FAAH. Comme résultat, il a été découvert qu'un composé azole substitué par un groupe N-(pyridin-3-yl)oxycarbonyl-pipéridin-4-yle et un groupe phényle ou un sel pharmaceutiquement acceptable de ceux-ci a une excellente activité inhibitrice sur la FAAH. Le composé a une excellente activité inhibitrice sur la FAAH, et il est confirmé que le composé a un effet anti-allodynique dans un modèle de douleur neurogénique du rat. Par conséquent, le composé est utile comme agent prophylactique et/ou thérapeutique pour la douleur neurogénique.
No affiliations
Astellas Pharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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