C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/08 (2006.01) A61K 31/41 (2006.01) C07D 233/60 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2217695
Compounds of formula (II), wherein R1 is chlorine, fluorine or trifluoromethyl; R2 is hydrogen, chlorine, fluorine or trifluoromethyl; Z is CH or N; R3, R4 and R5, the same or different are hydrogen or C1-C4 alkyl, provided that R4 is different from R5 when R3 is hydrogen; X is O or S; R6 is a C1-C5 polyfluoroalkyl group containing at least two fluorine atoms and optionally other halogen atoms selected among chlorine and bromine; and their salts with pharmaceutically acceptable acids, are described. The compounds of formula (II) are endowed with antimycotic activity for human and veterinary use.
La présente invention décrit des composés de formule (II), R¿1? représente chlore, fluor ou trifluorométhyle; R¿2? représente hydrogène, chlore, fluor ou trifluorométhyle; Z représente CH ou N; R¿3?, R¿4? et R¿5?, identiques ou différents, représentent hydrogène ou C¿1?-C¿4? alkyle, pourvu que R¿4? soit différent de R¿5? lorsque R¿3? est hydrogène; X représente O ou S; R¿6? est un groupe polyfluoroalkyle C¿1?-C¿5? contenant au moins deux atomes de fluor et facultativement d'autres atomes halogènes choisis parmi le chlore et le brome; ainsi que leurs acides pharmaceutiquement acceptables. Les composés de formule (II) présentent une activité antimycotique à usages humain et vétérinaire.
Albini Enrico
Schioppacassi Giovanna
Isagro S.p.a.
Riches Mckenzie & Herbert Llp
Zambon Group Spa
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