Azole derivatives and antimycotic and antiaromatase agents...

Details Azole derivatives and antimycotic and antiaromatase agents... Azole derivatives and antimycotic and antiaromatase agents...

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/41 (2006.01) A61K 31/70 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01) C07H 7/06 (2006.01)

Patent

CA 2095944

ABSTRACT OF THE DISCLOSURE Azole derivatives are represented by formula (I): Image (I) wherein R1 and R2 each are H or C1-C4 alkyl; R3 is H, OH, CN, halogen, haloalkyl, C1-C4 alkyl or phenyl, and if there are two or more R3 groups, such R3 groups may be the same or different; n is an integer from 0 to 5; Y is N or CH; and X is O, S or NH. The azole derivatives, stereoisomers; thereof, and pharmaceutically acceptable salts thereof have antimycotic and aromatase inhibitory activities. This invention also discloses compositions containing them, and a method of treating mycosis and estrogen-dependent diseases.

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