C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/60 (2006.01) A61K 31/41 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 233/54 (2006.01) C07D 233/61 (2006.01) C07D 233/68 (2006.01) C07D 249/08 (2006.01) C07D 257/04 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2463101
The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing various cancers, inflammation, septic shock, preterm labor, infertility, pain, and ischemia, and other diseases and disorders associated with MEK-1 and/or ERK-2 activation.
L'invention concerne des composés de pyrazolidinone substitués et des méthodes de traitement et des composition pharmaceutiques qui utilisent ou qui renferment un ou plusieurs de ces composés. Les composés de l'invention peuvent être utilisés dans diverses thérapies, y compris pour le traitement ou la prévention de divers cancers, de l'inflammation, du choc septique, de l'accouchement prématuré, de l'infertilité, de la douleur, de l'ischémie et d'autres maladies et troubles liés à l'activation de MEK-1 et/ou de ERK-2.
Arkinstall Stephen J.
Arulanandam Antonio
Blume-Jensen Peter
Jiang Xuliang
Magar Sharad
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
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