C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 495/10 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2487948
The present invention is related to azole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such azole derivatives. Said azole derivatives are modulators of the protein kinase signalling pathways, particularly the one involving c-Jun N- terminal kinase and/or Glycogen Kinase Synthase 3. The present invention is furthermore related to novel azole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1 -C6 alkyl; A is 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group.
L'invention concerne des dérivés d'azole s'utilisant notamment comme composés pharmaceutiquement actifs, de même que des formulations pharmaceutiques contenant des dérivés d'azole de ce type. Lesdits dérivés d'azole sont des modulateurs des voies de signalisation de la protéine kinase, notamment celles impliquant la c-Jun N-terminale kinase et/ou la glycogène kinase synthase 3. L'invention concerne en outre de nouveaux dérivés d'azole, de même que des procédés permettant de les préparer. (I) X désigne O, S ou NR?0¿, R?0¿ désignant H ou un alkyle C¿1?-C¿6? non substitué ou substitué ; A désigne un groupe 2-pyridyle, 3-pyridyle, 4-pyridyle, pyridazinyle, pyrimidinyle, pyrazinyle ou triazinyle.
Gaillard Pascale
Gotteland Jean-Pierre
Jeanclaude-Etter Isabelle
Schwarz Matthias
Thomas Russell J.
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
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