C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/423 (2006.01) A61K 31/424 (2006.01) A61K 31/428 (2006.01) A61K 31/429 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 277/72 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2437409
The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
La présente invention concerne, d'une part des procédés permettant le traitement de certaines affections du métabolisme, et d'autre part des composés et les promédicaments correspondants, et/ou certains de leurs sels pharmaceutiquement admis ainsi que des compositions pharmaceutiques à base de tels composés et convenant pour le traitement de telles affections. L'invention concerne plus particulièrement l'utilisation des composés et compositions de l'invention pour le traitement d'affections cardio-vasculaires, du diabète, des cancers, de l'acidose, et de l'obésité par l'inhibition de la décarboxylase des malonyl-CoA (MCD). Ces composés sont représentés par les formules (I) et (II) dans lesquelles Y, C, R¿1?, R¿2?, R¿6?, et R¿7? sont tels que défini dans la description.
Arrhenius Thomas
Cheng Jie Fei
Dyck Jason R.
Lopaschuk Gary D.
Nadzan Alex Michael
Chugai Seiyaku Kabushiki Kaisha
Torys Llp
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