Azolidinecarbonitriles and their use as dpp-iv inhibitors

Details Azolidinecarbonitriles and their use as dpp-iv inhibitors Azolidinecarbonitriles and their use as dpp-iv inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/421 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/497 (2006.01) A61P 3/10 (2006.01) C07D 263/04 (2006.01) C07D 401/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2534634

The invention discloses a novel heterocyclic compounds that falls within f the ambit of general formula (I), its stereoisomers, pharmaceutically acceptable salts or solvates wherein X, n,k,z, R1, R2, R3, R4, R5 and R6 are as defined in the specification that are useful in (i) normalizing elevated blood pglucose levels in diabetes, (ii) treating disorders related to glucose intolerance and (iii) for scavenging free radicals of mammals. The invention also discloses pharmaceutically acceptable composition comprising these compounds, method for preparation of the compounds as defined bove and method of treating mammals including human beings by administering an effective amount of said compounds to a subject in need thereof. The invention further discloses use of these compounds in the manufacture of a medicament useful for treatment of different disease conditions as stated above.

La présente invention se rapporte à de nouveaux composés hétérocycliques répondant à la formule générale (I), leurs stéréoisomères, leurs sels ou solvates pharmaceutiquement acceptables, formule dans laquelle X, n, k, z, R1, R2, R3, R4, R5 et R6 ont les significations définies dans la description, et trouvant application dans (i) la normalisation des taux élevés de glycémie chez les diabétiques, (ii) le traitement des troubles liés à l'intolérance au glucose, et (iii) la phagocytose des radicaux libres chez les mammifères. La présente invention se rapporte également à une composition pharmaceutiquement acceptable renfermant des composés de ce type, à un procédé de préparation des composés définis ci-dessus, et à un procédé de traitement de mammifères et notamment de l'homme par administration d'une quantité efficace desdits composés à un sujet qui en a besoin. Par ailleurs, l'invention se rapporte à l'application desdits composés à la fabrication d'un médicament utilisable dans le traitement de différents états pathologiques, comme précisé ci-dessus.

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