C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61K 31/5513 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2468156
The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des composés azolopyrimidinones utilisés pour traiter des maladies prolifératives cellulaires et des symptômes associés à l'activité de la kinésine KSP, et pour inhiber la kinésine KSP. La présente invention concerne également des compositions comprenant ces composés ainsi que des méthodes permettant de les utiliser pour traiter le cancer chez des mammifères.
Fraley Mark E.
Hartman George D.
Hoffman William F.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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