Azolopyrimidinones

Details Azolopyrimidinones Azolopyrimidinones

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 487/04 (2006.01) C07D 235/30 (2006.01) C07D 249/14 (2006.01) C07D 277/42 (2006.01) C07D 277/60 (2006.01) C07D 277/82 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1109870

ABSTRACT 6-(1H-tetrazol-5-yl) thiazolo(3,2-a)pyrimidin-5- ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol- 4-ones, and the corresponding imidazo- and trazolo- pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitroy action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxymethylenemalononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.

326912

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