Azolylacylguanidines as beta-secretase inhibitors

Details Azolylacylguanidines as beta-secretase inhibitors Azolylacylguanidines as beta-secretase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/32 (2006.01) A61P 25/28 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 411/12 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2597594

The present invention provides an azolylacylquanidine compound of formula (I). The present invention also provides methods for the use thereof to inhibit .beta.-secretase (BACE) and treat .beta.-amyloid deposits and neurofibrillary tangles.

La présente invention concerne un composé à base d'azolylacylguanidine représenté par la formule générale (I). La présente invention concerne également des méthodes dans lesquelles ce composé est utilisé pour inhiber la .beta.-secrétase (BACE) et pour traiter des dépôts de bêta-amyloïdes et des enchevêtrements neurofibrillaires.

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