Azolylmethylidenehydrazine derivative and use thereof

Details Azolylmethylidenehydrazine derivative and use thereof Azolylmethylidenehydrazine derivative and use thereof

C - Chemistry, Metallurgy

07

D

C07D 233/61 (2006.01) A61K 31/4174 (2006.01) A61K 31/4178 (2006.01) A61K 31/4196 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 29/00 (2006.01) A61P 31/10 (2006.01) A61P 37/08 (2006.01) C07D 249/08 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2692170

Disclosed is an azolylmethylenehydrazine derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof, which is useful as a pharmaceutical product, especially as an antifungal agent, an anti-inflammatory agent or an antiallergic agent. (I) (In the formula, Ar represents an optionally substituted aryl group or an optionally substituted heteroaryl group; R1 and R2 may be the same or different, and each represents an alkyl group, a cycloalkyl group, an optionally substituted aralkyl group, an optionally substituted aryl group or an optionally substituted heteroarylalkyl group, or alternatively R1 and R2 may combine together to form an optionally substituted nitrogen-containing heterocyclic group; and X represents a CH group or a nitrogen atom.) Disclosed is an azolylmethylidenehydrazine derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof, which is useful as a pharmaceutical product, especially as an antifungal agent, an anti-inflammatory agent or an antiallergic agent. (I) (In the formula, Ar represents an optionally substituted aryl group or an optionally substituted heteroaryl group; R1 and R2 may be the same or different, and each represents an alkyl group, a cycloalkyl group, an optionally substituted aralkyl group, an optionally substituted aryl group or an optionally substituted heteroarylalkyl group, or alternatively R1 and R2 may combine together to form an optionally substituted nitrogen- containing heterocyclic group; and X represents a CH group or a nitrogen atom.)

La présente invention concerne un dérivé d'azolylméthylènehydrazine représenté par la formule générale (I) ci-dessous ou un sel pharmacologiquement acceptable de celui-ci, qui est utile comme produit pharmaceutique, en particulier comme agent antifongique, agent anti-inflammatoire ou agent anti-allergique. (I) (Dans la formule, Ar représente un groupe aryle éventuellement substitué ou groupe hétéroaryle éventuellement substitué; R1 et R2 peuvent être identiques ou différents, et représentent chacun un groupe alkyle, un groupe cycloalkyle, un groupe aralkyle éventuellement substitué, un groupe aryle éventuellement substitué ou groupe hétéroarylalkyle éventuellement substitué, ou sinon R1 et R2 peuvent se combiner pour former un groupe hétérocyclique contenant de l'azote éventuellement substitué; et X représente un groupe CH ou un atome d'azote).

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