C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/18 (2006.01) A61K 31/473 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2629258
Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treament of cell proliferative disorders, in particular several forms of Cancer.
La présente invention concerne des dérivés d'azonafide préparés en faisant réagir de l'azonafide avec des aldéhydes, des halogénures d'acyle, des halogénures de thioacyle, des monoisocyanates, des isothiocyanates, des halogénures de sulfonyle, des monohalogénoalcanes, des monohalogénoalcènes ou des monohalogénoalcynes. Lesdits dérivés d'azonafide sont utilisables en tant que matière active dans des compositions pharmaceutiques destinées à la prévention et au traitement de dérèglements de la prolifération cellulaire, en particulier de plusieurs formes de cancer.
Darro Francis
Kiss Robert
Tuti Jerome
Van Den Hove Laurent
Van Quaquebeke Eric
Smart & Biggar
Unibioscreen S.a.
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