Azulene hydroxamic acid derivatives as metalloprotein...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 295/12 (2006.01) A61K 31/015 (2006.01) A61K 31/16 (2006.01) C07C 239/20 (2006.01) C07C 259/06 (2006.01) C07C 271/60 (2006.01) C07D 295/088 (2006.01) C07D 295/185 (2006.01) C07D 317/22 (2006.01) C07D 317/30 (2006.01) C07F 9/38 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2313239

The invention provides novel azulene derivatives of general formula (I) wherein R1 to R6 have the significance given in the description, as well as their tautomers, enantiomers, diastereomers, racemates and physiologically compatible salts or esters and substances which are hydrolyzed or metabolised in vivo to compounds of formula (I). The invention is also concerned with a process and intermediates for the manufacture of the above compounds, medicaments which contain such compounds as well as the use of these compounds in the production of medicaments having metalloprotein-inhibiting activity.

La présente invention concerne de nouveaux dérivés d'azulène représentés par la formule générale (I), dans laquelle R¿1? à R¿6? sont tels que définis dans la description, de même que pour leurs tautomères, énantiomères, diastéréomères, racémates et sels et esters physiologiquement compatibles, ainsi que des substances hydrolysées ou métabolisées in vivo en composés de la formule (I). Cette invention concerne par ailleurs un procédé et des produits intermédiaires utilisés dans la fabrication des composés précités, des médicaments contenant de tels composés, ainsi que l'utilisation de ces composés dans la production de médicaments ayant une activité inhibitrice des métalloprotéines.

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