B. burgdorferi polypeptides expressed in vivo

Details B. burgdorferi polypeptides expressed in vivo B. burgdorferi polypeptides expressed in vivo

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) C07K 14/20 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2253834

Methods and compositions for the prevention, treatment and diagnosis of Lyme disease. Novel B. burgdorferi polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof. Fusion proteins and multimeric proteins comprising same. Multicomponent vaccines comprising novel B. burgdorferi polypeptidesin addition to other immunogenic B. burgdorferi polypeptides. DNA sequences, recombinant DNA molecules and transformed host cells useful in the compositions and methods. Antibodies directed against the novel B. burgdorferi polypeptides, and diagnostic kits comprising the polypeptides or antibodies. A method for identifying bacterial genes that are selectively expressed in vivo.

L'invention porte: sur des procédés et compositions servant à la prévention, au traitement et au diagnostic de la maladie de Lyme; sur de nouveaux polypeptides du type B. burgdorferi, leurs variantes sérotypiques, leurs fragments et leurs dérivés; sur des protéines de fusion et des protéines multimères les incluant; sur des vaccins à plusieurs composants contenant les nouveaux polypeptides du type B. burgdorferi, ainsi que d'autres polypeptides immunogènes du type B. burgdorferi; sur des séquences d'ADN, des molécules d'ADN de recombinaison et des cellules hôtes transformées utiles dans les procédés et compositions ci-dessus; sur des anticorps dirigés contre les nouveaux polypeptides du type B. burgdorferi et des trousses de diagnostic comportant lesdits polypeptides ou anticorps; et sur une méthode d'identification de gènes de bactéries exprimés sélectivement in vivo.

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