B-cell reduction using cd37-specific and cd20-specific...

Details B-cell reduction using cd37-specific and cd20-specific... B-cell reduction using cd37-specific and cd20-specific...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 21/04 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2616395

The present application generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The application further provides materials and methods for application treatment of diseases involving aberrant B-cell activity. In addition, the application provides humanized CD37-specific binding molecules.

D'une manière générale, la présente invention a trait à des procédés pour la réduction de lymphocytes B chez un individu au moyen de molécules de liaison spécifique de CD37. En particulier, l'invention a trait à des procédés pour la réduction de lymphocytes B au moyen de molécules de liaison spécifique de CD37, ou d'une combinaison de molécules de liaison spécifique de CD37 et de molécules de liaison spécifique de CD20, dans certains cas une combinaison synergique. L'invention a également trait à des substances et des procédés de traitement de maladies impliquant une activité aberrante de lymphocytes B. L'invention a trait en outre à des molécules de liaison spécifique de CD37 humanisées.

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