[b]-fused bicyclic proline derivatives and their use for...

Details [b]-fused bicyclic proline derivatives and their use for... [b]-fused bicyclic proline derivatives and their use for...

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) A61K 31/401 (2006.01) A61P 19/00 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2522195

The invention relates to a compound which is [b]-fused bicyclic proline derivative, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the salt thereof, and methods of treating diseases, including, but not limited to, methods of preventing or inhibiting joint cartilage damage and preventing or treating diseases characterized by joint cartilage damage, joint inflammation, or joint pain. The [b]-fused bicyclic proline derivatives are compounds of Formula I as described above. Diseases characterized by joint cartilage damage or joint pain include, for example, osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is also characterized by joint inflammation. This invention also relates to methods of synthesizing and preparing the [b]-fused bicyclic proline derivatives, or a pharmaceutically acceptable salt thereof.

L'invention concerne un composé qui est un dérivé bicyclique [b]-fusionné de proline ou un de ses sels pharmaceutiquement acceptables ; une composition pharmaceutique qui contient le composé ou un de ses sels, et des méthodes de traitement de maladies, y compris mais non seulement des méthodes de prévention ou d'inhibition de lésions des cartilages des articulations et de prévention ou de traitement de maladies caractérisées par des lésions des cartilages des articulations, des inflammations des articulations ou des douleurs aux articulations. Les dérivés bicycliques [b]-fusionnés de proline sont des composés de formule I du type décrit ci-dessus. Les maladies caractérisées par des lésions des cartilages des articulations ou des douleurs aux articulations comprennent, par exemple, l'ostéoarthrose et la polyarthrite rhumatoïde. La polyarthrite rhumatoïde est également caractérisée par l'inflammation des articulations. L'invention concerne également des méthodes pour synthétiser et préparer les dérives bicycliques [b]-fusionnés de proline ou un de leurs sels pharmaceutiquement acceptables.

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